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FUNCTIONAL GENOMICS

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FUNCTIONAL GENOMICS

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Academic year 2023/2024

Course ID
BIO0167 Pds 306-TB
Teachers
Alberto Bardelli
Mara Brancaccio
Degree course
[0101M22] Molecular Biotechnology
Year
1st year
Teaching period
First semester
Type
Distinctive
Credits/Recognition
8
Course disciplinary sector (SSD)
BIO/13 - experimental biology
BIO/17 - histology
Delivery
Formal authority
Language
English
Attendance
Obligatory
Type of examination
Oral
Prerequisites
To understand the contents of the class, students should have a solid background on General Biology, Genetics, Cell Biology, Biochemistry, Organic Chemistry, Molecular Biology, Molecular Genetics.
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Sommario del corso

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Course objectives

The course tackles advanced topics of gene regulation at the genomic and post-transcriptional level. These aspects are presented in two modules: (1) The Genetic Basis of Cancer, which uses cancer as a paradigm to understand genomic (dys)regulation of cell function: and (2) Molecular Dynamics of Cellular Processes, which examines post-translational in different systems.

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Results of learning outcomes

Students will gain both broad knowledge on the latest discoveries in the functional genomics field, and the critical thinking and analysis skills needed to keep up with this rapidly moving area.

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Program

Module 1 - The Genetic Basis of Cancer

Cancer: a genetic disease. The causes of cancer. Genetic alterations and tumor progression. Cancer genes: Oncogenes, Tumor Suppressor genes, Gatekeepers and Caretakers. Tumor related mutational signatures. Patient derived models (cells, organoids and PDX) to study tumor progression and response to therapy. Genetic profiling of human tumors. Genetic basis of targeted cancer therapy. Diagnosis and personalized treatment. Genomic driven biomarkers.

 

Module 2 – Molecular Dynamics of Cellular Processes

The program is based on the deepening of key scientific issues coming out in recent publications. The topics covered will address the molecular mechanisms underlying post-translational regulation involved in protein folding and degradation, and regulation of stress responses. These aspects will be examined in different areas of biomedicine, including cancer, neural, cardiovascular, and immune biology.

 

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Course delivery

Frontal lessons with a high degree of interactivity to stimulate discussion of the topics presented.

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Learning assessment methods

Oral examination. The oral tests will be evaluated based on critical thinking skills, the quality of the presentation and knowledge of the subjects of the course. The critical discussion of a scientific publication is an integral part of the exam. The vote will be expressed as a fraction of 30 (eventually cum laude) and will represent the average of the marks of the all Functional Genomics modules.

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Support activities

Laboratory activities carried out by the students for their thesis are considered as practical exercises

Suggested readings and bibliography

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The course deals with scientific topics in constant development and accordingly it is not possible to indicate a reference text. Attendance is highly recommended.



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Teaching Modules

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    Last update: 20/07/2023 15:53
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