METALS IN MEDICINE AND BIOLOGICAL SYSTEMS
Metals in medicine and biological systems
Academic year 2022/2023
- Course ID
- BIO0218 Pds GEN
- Prof. Giuseppe Ferrauto
- Degree course
- [0101M21] Molecular Biotechnology
- 2nd year
- Teaching period
- First semester
- Course disciplinary sector (SSD)
- CHIM/03 - general and inorganic chemistry
- Formal authority
- Type of examination
- Written and oral
- Type of learning unit
- General and Inorganic chemistry
Basis of organic chemistry (functional groups)
Basis of chemical spectroscopies
Sommario del corso
Results of learning outcomes
The course merges knowledges of chemistry with knolwedges of cell biology.
Students will know the role of metals in biological systems, their use for therapy and diagnosis and the diseases correlated to metals.
Group of students will deepen a topic related to the role of metals in biological systems and/or in medicine and will prepare a written work on this research. In this way they will improve soft skills as:
- Time management.
- Public speaking.
1.Introduction on the use of metals in medicine.
2.Basis of chemistry of metals and general properties of metal ions.
3.Metal ions in biological systems: Metabolism, nutritional aspects, structure of active sites in metalloproteins and metalloenzymes, mechanistic and physico-chemical characterization, biomimetic chemistry, binding and transport of O2, electronic transfer, activation of small molecules by metal ions.
4.Metals in therapy and diagnostic
a.Metal based contrast agents for MRI, TC, US, optical imaging and PAI;
b.Radiopharmaceuticals in Nuclear Medicine for radiotherapy and diagnostic;
c.Metals complexes as: anticancer, antiviral, antimicrobial, anti arthritis, antiulcer drugs, in neurosciences;
d.Metals in gene therapy and antisense technology;
5.In vitro diagnostic tools based on metals. Biosensors.
6.Metals in the environment, chemical speciation, biological cycles, biotransformation, bioacumulation, molecular mechanisms of toxicity and metals induced diseases.
The course will be an experimentation of "flipped classroom". Part of the lessons will be in presence and part of them will be on-line.
The course will be divided into three steps:
1) Theoretical lessons where students will be introduced by the teacher to the role of metals in biological systems and in medicine (in presence and /or pre-recorded).
2) Supervised deeping of chosen topics and reading/analysis of papers about the use of metals in medicine.
3) Preparation of a group written report on the chosen topic.
4) Collegial activity of reflection on the executed work.
All parts of the work will be guided by the teacher in a continuous exchange of information.
Learning assessment methods
The final exam will the preparation of a written paper on a chosen topic related to the course.
The work will be a group acrivity consisting in i) choice of topic (in agreement with the teacher), ii) study of problem and analysis of bibliography, iii) preparation of a written report on the topic.
The teacher is avaiable for any question or doubt through mail, face to face or webex meetings
Suggested readings and bibliography
Le modalità di svolgimento dell'attività didattica potranno subire variazioni in base alle limitazioni imposte dalla crisi sanitaria in corso. In ogni caso è assicurata la modalità a distanza per tutto l'anno accademico.
Students are required to register for the course both on campusnet (https://biotec.campusnet.unito.it) and on the Moodle (https://biotec.i-learn.unito.it) platform.
The didactic material will be present on both platforms.