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METALS IN MEDICINE

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Metals in medicine

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Academic year 2020/2021

Course ID
BIO0177 Pds GEN
Teacher
Dott. Giuseppe Ferrauto
Degree course
[0101M21] Molecular Biotechnology
Year
2nd year
Teaching period
To be defined
Type
Elective
Credits/Recognition
3
Course disciplinary sector (SSD)
CHIM/03 - chimica generale e inorganica
Delivery
Formal authority
Language
English
Attendance
Obligatory
Type of examination
Oral
Prerequisites
General and Inorganic chemistry
Basis of organic chemistry (functional groups)
Biological macromolecules
Basis of chemical spectroscopies
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Sommario del corso

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Course objectives

The main aims of this course are:

-Understanding the chemo-physical properties of the most important classes of metal elements (noble metals, transitions metals, lanthanides) and their interaction with biological systems;

-understanding of the role of metal ions and respective complexes in Medicine (both in therapy and in diagnostic field);

- knowing the structural and catalitic function of metals in metalloproteins, their role on the control of different biological processes;

-understanding the  toxic effects of overloading of metals in biological systems

-knowing the main diseases caused by over accumulation or deficiency of metals

-understanding the effect of environmental contamination by metals on human health

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Results of learning outcomes

Students will know the role of metals in biological systems, their use for therapy and diagnosis and the diseases correlated to metals.

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Course delivery

Course will consist in oral lessons (in presence or e-learning, depending on the situation), with the analysis of some papers about the use of metals in medicine.

 

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Learning assessment methods

The final exam will be in oral form + presentation of a report

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Support activities

The teacher is avaiable for any question or doubt through mail, face to face or webex meetings

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Program

1.Introduction on the use of metals in medicine.

2.Basis of chemistry of metals and general properties of metal ions.

3.Metal ions in biological systems: Metabolism, nutritional aspects, structure of active sites in metalloproteins and metalloenzymes, mechanistic and physico-chemical characterization, biomimetic chemistry, binding and transport of O2, electronic transfer, activation of small molecules by metal ions.

4.Metals in therapy and diagnostic

a.Metal based contrast agents for MRI, TC, US, optical imaging and PAI;

b.Radiopharmaceuticals in Nuclear Medicine for radiotherapy and diagnostic;

c.Metals complexes as: anticancer, antiviral, antimicrobial, anti arthritis, antiulcer drugs, in neurosciences;

d.Metals in gene therapy and antisense technology;

5.In vitro diagnostic tools based on metals. Biosensors.

6.Metals in the environment, chemical speciation, biological cycles, biotransformation, bioacumulation, molecular mechanisms of toxicity and metals induced diseases.

 

 

The following classes of metals will be analysed:

a) transition metals (Fe, Mn, Co, Ni, ...)

b) lanthanides (Gd, Eu, Yb,...)

c) noble metals (Au, Ag, Cu, Pt)

 

 

Suggested readings and bibliography

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Slides, power points with audio comments and review will be provided by the teacher. 

Some suggested books are the following ones:

1.“Principles of Bioinorganic Chemistry”, S. J.Lippard e J. M. Berg, (1994), University Science Books, Mill Valley, Califórnia.

2.“Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life”,W. Kaim e B. Schwederski, (1994), Wiley, Chichester, U.K.

3. “Biocoordination Chemistry”, D. E. Fenton, (1995), Oxford University Press, Oxford, U.K.

4. “Inorganic Biochemistry”, J.A. Cowan, (1997), Wiley-VCH, New York.

5. “The Biological Chemistry of the Elements”, J.J. Fraústo da Silva e R.J.P. Williams (1991), Clarendon Press, Oxford, U.K.

6. “Bringing Chemistry to Life- from Matter to Man”,(1999), R.J.P. Williams e J.J. Fraústo da Silva, Oxford University Press, Oxford, U.K.

7. "Metal Ions in Biological Systems", H.Sigel Ed., Marcel Dekker, New York, 1974-1996, vols 1-presente.

 



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Note

Le modalità di svolgimento dell'attività didattica potranno subire variazioni in base alle limitazioni imposte dalla crisi sanitaria in corso. In ogni caso è assicurata la modalità a distanza per tutto l'anno accademico.

 

Students are required to register for the course both on campusnet (https://biotec.campusnet.unito.it) and on the Moodle (https://biotec.i-learn.unito.it) platform.

The didactic material will be present on both platforms.

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Last update: 01/10/2020 17:48
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