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PET/SPECT/CT

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PET/SPECT/CT

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Academic year 2021/2022

Course ID
BIO0155A Pds 307-DDD
Teacher
Prof.ssa Désirée Deandreis (Lecturer)
Degree course
[0101M21] Molecular Biotechnology
Year
1st year
Teaching period
To be defined
Type
Distinctive
Credits/Recognition
5
Course disciplinary sector (SSD)
MED/36 - diagnostica per immagini e radioterapia
Delivery
Formal authority
Language
English
Attendance
Obligatory
Type of examination
Oral
Type of learning unit
modulo
Modular course
IN VIVO DIAGNOSTICS (BIO0155 Pds 307-DDD)
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Sommario del corso

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Course objectives

• To provide basic and advanced knowledge concepts in Nuclear Medicine and Molecular Imaging, applied both to basic science and clinical practice.

• To introduce the current and potential application of the different radiopharmaceuticals, applied both for diagnostic and therapeutic purposes. Namely, will be introduced the pre-clinical and clinical appliation of radio-ligand therapy in different cancer phenotypes.

• To introduce the concept of translational imaging ("from bench to the bedside").

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Results of learning outcomes

• Knowledge and applicability of different radiopharmaceuticals related to clinical oncology, neurology, basic science and cardiology. 

• Completing the course, students should have learned the princiapl indications regarding different hybrid diagnostic techniques (PET/CT, PET/MRI, SPECT/CT) and be able to understand the potential clinical application and the usefulness in pre-clinical practice.

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Program

  • Basic concepts of clinical application of PET and SPECT imaging in medicine.
  • Overview about technical aspects of PET and SPECT tomographs.
  • Overview about a pre-clinical (laboratory) and clinical (hospital) facilities for nuclear medicine and molecular imaging.
  • Synthesis and Production of PET radiopharmaceuticals using a Gallium-68 Generator
  • Synthesis and Production of PET radiopharmaceuticals using a cyclotron facility
  • PET radiopharmaceuticals for imaging glucose metablosim
  • PET radiopharmaceuticals for imaging different cancer phenotypes
  • Clinical and Pre-clinical application of PET imaging in Endocrinology
  • Clinical and Pre-clinical application of PET imaging in Neurology and degenerative disorders
  • Clinical and Pre-clinical application of SPECT in Cardiology
  • Clinical and Pre-clinical application of PET and SPECT imaging for investigating Neuroendocrine Tumors
  • Theranostics approach in Neuroendocring Tumors trough the identification of the somatostatin receptors.
  • Novel radiopharmaceuticals for PET imaging in prostate cancer (PSMA, choline, fluciclovine).
  • Diagnostic application of inhibitor of the Fibroblast Activating Protein (FAPi) in PET imaging. 
  • Role of PET imaging in Hypoxia
  • Clinical and preclinical application of PET imaging for evaluating the response to therapy in oncology, with a dedicated focus on Immunotherapy
  • Theranostics approach for investigating the Gastrin Release Peptide Receptor (GRPR or Bombesin)
  • Design and concept of Novel Radiopharmaceuticals: how does it work?
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Course delivery

40 hours, formal lectures.

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Learning assessment methods

Oral Test

Suggested readings and bibliography

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Students will receive lecturer presentations together with support material, including scientific review or original articles and/or book chapters specific for each lecture.



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Notes

Le modalità di svolgimento dell'attività didattica potranno subire variazioni in base alle limitazioni imposte dalla crisi sanitaria in corso. In ogni caso è assicurata la modalità a distanza per tutto l'anno accademico

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