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DRUG DISCOVERY: BASIC PRINCIPLES

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Drug Discovery: basic principles

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Academic year 2018/2019

Course ID
BIO0156 Pds 307-DDD
Teacher
Dott. Sonja Visentin
Degree course
[0101M21] Molecular Biotechnology
Year
1st year
Type
Related or integrative
Credits/Recognition
5
Course disciplinary sector (SSD)
CHIM/08 - chimica farmaceutica
Delivery
Formal authority
Language
English
Attendance
Obligatory
Type of examination
Written and oral
Prerequisites
Understanding the contents of the course requires solid background in peptides/protein structure, and basic knowledge of organic and analytical chemistry
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Sommario del corso

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Course objectives

The main objective of the course is to provide students with the basics of drug discovery and understanding the relationship between the chemical structure of molecules and their pharmacological activity. Moreover, the course prefigures to provide the student with a highly professionalized competence in the field of business , national and international pharmaceutical research centers, on the different aspects of instrumental analysis in the different phases of the discovery, development and production process  of the pharmaceutical industry.

 

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Results of learning outcomes

At the end of the course, students should be able to have learned the various stages that make up the pipeline of drug discovery and understand the chemical and physical properties of the molecules in the pharmaceutical field 

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Course delivery

The course will be delivered through frontal lectures using the Moodle platform

Lessons: 40 hours

Credits: 5

An educational visit to a pharmaceutical company (in 2015-2016/2016-2017,Chiesi Farmaceutici , Parma,) if possible, will be organized.  

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Learning assessment methods

The exam is divided in  two parts:

  • writing a scientific article about a drug assigned to each candidate at least 15 days before the examination date, using a track provided by the teacher (max 27/30)
  • Oral exam on the program

The unit of measure: thirty/30 

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Program

  • Introduction to drug discovery ; identification of the target and the ligand ; virtual screening ; drug discovery based on fragments ; transformations of lead ; isosterism and bioisosterism ; Introduction to QSAR ; synthesis of peptides and SPPS ; Combinatorial Approach to Drug Discovery ; example of study .
  • Physico-chemical properties of molecules and their influence on the interaction between drugs and their targets :
  1. type of bond and their strength, intermolecular forces, ionization, lipophilicity
  2.  Relevance of the structures of proteins and DNA drug-receptor interaction
  3. Principles of Pharmacodynamics Pharmacokinetics ( ADMET )
  4. Molecular Descriptors involved in the determination of the ADME profile of potential drugs
  5. Principles of Pharmacodynamics Pharmacokinetics ( ADMET )
  6. Structure- activity relationship and drug design
  7. Drug Discovery for biotechnological drugs 
  8. Nanotechnology for drug delivery 

Suggested readings and bibliography

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Burger's Medicinal Chemistry and Drug Discover

Author: Donald Abraham and David Rotella
Publisher: Wiley
ISBN: 978-0-470-27815-4

Pharmaceutical Analysis
Author: David Watson
Publisher: Elsevier
ISBN: 9780702051296



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Last update: 20/05/2018 18:29
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