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ENABLING TECHNOLOGIES IN DRUG SYNTHESIS AND PROCESSING

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ENABLING TECHNOLOGIES IN DRUG SYNTHESIS AND PROCESSING

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Academic year 2021/2022

Course ID
BIO0189 Pds GEN
Teacher
Prof. Giancarlo Cravotto (Lecturer)
Degree course
[0101M21] Molecular Biotechnology
Year
2nd year
Teaching period
Second semester
Type
Elective
Credits/Recognition
4
Course disciplinary sector (SSD)
CHIM/06 - chimica organica
Delivery
Formal authority
Language
English
Attendance
Obligatory
Type of examination
Oral
Prerequisites
General knowledge on chemistry and biology are of paramount importance for proficiently following the course. Knowledge of fundamentals of analytical chemistry is strongly encouraged.
Propedeutic for
A modern view of pharmaceutical strategies within the Industry 4.0, where new enabling technologies may improve efficiency and products quality from drug discovery to the industrial production.
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Sommario del corso

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Course objectives

    The formative path of this course leads to the ability of understanding and designing more sustainable ecofriendly procedures for pharmaceutical industry starting from laboratory scale toward pilot scale plant. A number of technologies for process intensification will be widely discussed.

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Results of learning outcomes

The formative path of this course leads to the ability of understanding and evaluating the critical parameters to be considered during the scale up of a pharmaceutical routes from laboratory to pilot plant according to SELECT (Safety, Environmental, Legal, Economic, Control, Throughput) rules.

By the end of the course, students will be able to apply the acquired knowlwedge to simple scale up problems and to competently discuss about process development issues with experts in the field.

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Course delivery

Seminars and case studies will be illustrated In the body of the course either by teachers or by process development experts from industry.

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Learning assessment methods

Oral discussion

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Support activities

Link to relevant web sites

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Program

Safety, toxicity, and environmental impact in process development. Reagents, catalysts for large scale synthesis. Synthetic startegies and application of organic chemistry reactions in process development. Process monitoring and industrial purifictaion techniques. Industrial approach to green and sustainable chemistry. Industrial application of non-conventional synthetic techniques: synthetic and extraction processes assisted by ultrasound (sonochemistry) and microwaves. Synthesis solvent-free by mechanochemical routes with ball mills and extruders. Synthesis in continuous-flow reactors. Photochemistry and reactors with LED and plasma. Hybrid technologies. Case studies.

Suggested readings and bibliography

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Reviews provided by the Professor



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Note

Le modalità di svolgimento dell'attività didattica potranno subire variazioni in base alle limitazioni imposte dalla crisi sanitaria in corso. In ogni caso è assicurata la modalità a distanza per tutto l'anno accademico

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AppelliV

 DateHoursExam
03/06/2022 13:00 - 14:00 Oral
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Last update: 01/05/2022 21:23
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