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ENABLING TECHNOLOGIES IN DRUG SYNTHESIS AND PROCESSING
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ENABLING TECHNOLOGIES IN DRUG SYNTHESIS AND PROCESSING
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Academic year 2020/2021
- Course ID
- BIO0189 Pds GEN
- Teacher
- Prof. Giancarlo Cravotto (Lecturer)
- Degree course
- [0101M21] Molecular Biotechnology
- Year
- 2nd year
- Teaching period
- Second semester
- Type
- Elective
- Credits/Recognition
- 4
- Course disciplinary sector (SSD)
- CHIM/06 - chimica organica
- Delivery
- Formal authority
- Language
- English
- Attendance
- Obligatory
- Type of examination
- Oral
- Prerequisites
- General knowledge on chemistry and biology are of paramount importance for proficiently following the course. Knowledge of fundamentals of analytical chemistry is strongly encouraged.
- Propedeutic for
- A modern view of pharmaceutical production where new enabling technologies may improve efficiency and quality
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Sommario del corso
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Course objectives
The formative path of this course leads to the ability of understanding and designing more sustainable ecofriendly procedures for pharmaceutical industry starting from laboratory scale toward pilot scale plant. A number of technologies for process intensification will be widely discussed.
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Results of learning outcomes
The formative path of this course leads to the ability of understanding and evaluating the critical parameters to be considered during the scale up of a pharmaceutical routes from laboratory to pilot plant according to SELECT (Safety, Environmental, Legal, Economic, Control, Throughput) rules.
By the end of the course, students will be able to apply the acquired knowlwedge to simple scale up problems and to competently discuss about process development issues with experts in the field.
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Course delivery
Seminars and case studies will be illustrated In the body of the course either by teachers or by process development experts from industry.
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Learning assessment methods
Oral discussion
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Support activities
Link to relevant web sites
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Program
Safety, toxicity, and environmental impact in process development. Reagents, catalysts for large scale synthesis. Synthetic startegies and application of organic chemistry reactions in process development. Process monitoring and industrial purifictaion techniques. Industrial approach to green and sustainable chemistry. Industrial application of non-conventional synthetic techniques: synthetic and extraction processes assisted by ultrasound (sonochemistry) and microwaves. Synthesis solvent-free by mechanochemical routes with ball mills and extruders. Synthesis in continuous-flow reactors. Photochemistry and reactors with LED and plasma. Hybrid technologies. Case studies.
Suggested readings and bibliography
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Reviews provided by the Professor
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Note
Le modalità di svolgimento dell'attività didattica potranno subire variazioni in base alle limitazioni imposte dalla crisi sanitaria in corso. In ogni caso è assicurata la modalità a distanza per tutto l'anno accademico
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