Master Program in Molecular Biotechnology

MOLECULAR MEDICINAL CHEMISTRY

Molecular Medicinal Chemistry

Academic year 2022/2023

Sommario del corso

• Course objectives
• Results of learning outcomes
• Course delivery
• Learning assessment methods
• Support activities
• Program
• Suggested textbooks and readings
• Notes
• Teaching tools

Course objectives

What is a drug? This medicinal chemistry course explores how chemists modify a molecule’s structure to design a safe and effective drug.

Results of learning outcomes

At the end of the course the student will be able to read critically paper in the field of the drug discovery and have a knowledge of the  process that a molecule must do to become a drug

Course delivery

The course will be delivered in blended learning.

Lessons will take place in the classroom or in remote presence according to the guidelines provided by the university.

A student is required to attain at least 75% of the attendance for lectures, tutorials and practical sessions of the course (in classroom or in remote presence).

Learning assessment methods

Preparation and discussion of infographics on some topics of the course.

Preparation and discussion of a report on topics related to the program of the course.

Exams will be conducted 'face-to-face' or online according to university guidelines.

Support activities

Use of the e-learning platform Moodle

Program

Pre-Regulatory Medicine and the Drug Approval Process: Modern drug discovery and approval process for the Intellectual property issues with drugs.

Drug pipeline with some example of drugs that changed the life of patients. Drug screening, Filtering hits to find leads Existing drugs and natural products as leads

Drug Targets: Structure of proteins Enzymes and other targets. 

Binding, Structure, and Diversity Intermolecular forces.

Molecular diversity and chemical libraries Combinatorial chemistry

Metabolism: Types of metabolic reactions. How can we use metabolism to obtain safe and effective drugs

The Organic Chemistry of Drug Design and Drug Action
Autore: Richard B. Silverman, Mark W. HollodayEdizione: Third Edition
Casa editrice: Academic Press
ISBN: 9780123820303
Url: https://www.elsevier.com/books/the-organic-chemistry-of-drug-design-and-drug-action/silverman/978-0-12-382030-3

The Practice of Medicinal Chemistry
Autore: Camille Wermuth, David Aldous, Pierre Raboisson, Didier RognanEdizione: Fourth Edition
Casa editrice: Academic Press
ISBN: 9780124172050
Url: https://www.elsevier.com/books/the-practice-of-medicinal-chemistry/wermuth/978-0-12-417205-0

Note

Le modalità di svolgimento dell'attività didattica potranno subire variazioni in base alle limitazioni imposte dalla crisi sanitaria in corso. In ogni caso è assicurata la modalità a distanza per tutto l'anno accademico

• Teaching materials
• Exams and finals
• Go to Moodle
• Visit the forums