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Molecular Therapy in Nephrology

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Terapie molecolari in Nefrologia

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Academic year 2022/2023

Course ID
BIO0144
Teacher
Prof.ssa Benedetta Bussolati
Modular course
Degree course
[0101M21] Molecular Biotechnology
Year
2nd year
Type
Distinctive
Credits/Recognition
7
Course disciplinary sector (SSD)
MED/14 - nephrology
Delivery
Formal authority
Language
Italian
Attendance
Obligatory
Type of examination
Oral
Prerequisites
Basic knowledge on physiology, histology, cell and molecular biology and immunology.
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Sommario del corso

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Course objectives

Knowledge of the molecular and cellular mechanisms involved in the pathogenesis of the main kidney diseases  and of bio-technological techniques for their therapy.

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Results of learning outcomes

Knowledge of the molecular and cellular mechanisms involved in the pathogenesis of the main kidney diseases  and of bio-technological techniques for their therapy, with specific focus on regenerative medicine.

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Course delivery

Frontal lessons and presentation/discussion of literature papers.

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Learning assessment methods

Oral examination

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Program

Pathogenetic mechanisms and development of molecular therapies:

Alterations of the immune system responsible for glomerular and tubulo-interstitial damage, autoimmunity, mechanism of the immune complex deposition. Strategies for the induction of tolerance. Mechanisms of glomerular permeability.

Allotransplant:

molecular and cellular mechanisms involved in the main clinical complications, theory and methodology for the development of techniques  aimed to induce a specific immuno-suppression, tolerance or to modify the organ immunogenicity.

- Xenotranplant:

antigens and molecular mechanisms involved in the rejection of a xenogenic transplant, theory and methodology for the development of techniques  aimed to improve the biocompatibility.

 -Regenerative medicine:

Resident and bone-marrow derived stem cells in the regeneration of the glomerular and tubular damage; stem cells and gene therapy, bioreactors. 

Suggested readings and bibliography

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Didactic material (slides, text and articles) provided.  



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