Master Program in Molecular Biotechnology

Molecular Therapy in Nephrology

Terapie molecolari in Nefrologia

Academic year 2019/2020

• THERAPEUTIC BIOTECHNOLOGY (BIO0169 Pds 306-TB)

Sommario del corso

• Course objectives
• Results of learning outcomes
• Course delivery
• Learning assessment methods
• Program
• Suggested textbooks and readings
• Teaching tools

Course objectives

Knowledge of the molecular and cellular mechanisms involved in the pathogenesis of the main kidney diseases  and of bio-technological techniques for their therapy.

Results of learning outcomes

Knowledge of the molecular and cellular mechanisms involved in the pathogenesis of the main kidney diseases  and of bio-technological techniques for their therapy, with specific focus on regenerative medicine.

Course delivery

Frontal lessons and presentation/discussion of literature papers.

Learning assessment methods

Oral examination

Program

- Pathogenetic mechanisms and development of molecular therapies:

Alterations of the immune system responsible for glomerular and tubulo-interstitial damage, autoimmunity, mechanism of the immune complex deposition. Strategies for the induction of tolerance. Mechanisms of glomerular permeability.

- Allotransplant:

molecular and cellular mechanisms involved in the main clinical complications, theory and methodology for the development of techniques  aimed to induce a specific immuno-suppression, tolerance or to modify the organ immunogenicity.

- Xenotranplant:

antigens and molecular mechanisms involved in the rejection of a xenogenic transplant, theory and methodology for the development of techniques  aimed to improve the biocompatibility.

 -Regenerative medicine:

Resident and bone-marrow derived stem cells in the regeneration of the glomerular and tubular damage; stem cells and gene therapy, bioreactors. 

Didactic material (slides, text and articles) provided.  

• Teaching materials
• Exams and finals
• Go to Moodle
• Visit the forums