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IN VIVO IMAGING OF CANCER THERAPY

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IN VIVO IMAGING OF CANCER THERAPY

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Academic year 2019/2020

Course ID
BIO0188 Pds GEN
Teacher
Dott. Dario Livio Longo (Lecturer)
Degree course
[0101M21] Molecular Biotechnology
Year
2nd year
Type
Elective
Credits/Recognition
4
Course disciplinary sector (SSD)
CHIM/03 - chimica generale e inorganica
CHIM/08 - chimica farmaceutica
MED/36 - diagnostica per immagini e radioterapia
Delivery
Formal authority
Language
English
Attendance
Obligatory
Type of examination
Oral
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Sommario del corso

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Course objectives

The main objective of the course is to provide students with the basics of in vivo imaging techniques and to highlight pros and cons in the characterization of tumour metabolism and microenvironment. Moreover, the course will highlight the use of imaging techniques in the drug development process and for assessing therapeutic response in oncological applications at both preclinical and clinical level. 

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Results of learning outcomes

At the end of the course, students will have understood the several (functional) information that imaging techniques can provide to investigate non-invasively cancer pathologies and will have acquired which methods are more suitable to assess the efficacy of drugs according to their mechanism of action.

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Course delivery

The course will be delivered through frontal lectures

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Learning assessment methods

Student presentation, in 15 minutes, of a scientific paper (provided by the teacher) related to the main topics of the program. The teachers will evaluate the ability of the student to:

  • clearly illustrate the objective, including a detailed description of the exploited imaging approach
  • present the data
  • critically discuss the results

The grade is expressed through a 30-points scale (minimum 18/30; maximum 30/30).

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Program

  • Introduction to imaging in cancer screening and diagnosis
  • Imaging-derived biomarkers in drug discovery
  • Basic introduction to imaging techniques (MRI, CT, PET/SPECT)
  • Imaging techniques to assess treatment response in oncology
    • Imaging techniques for tumor volume measurements
    • In vivo imaging of tumor perfusion
    • In vivo imaging of tumor metabolism
    • In vivo imaging of tumor acidosis

Suggested readings and bibliography

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  • Scientific articles presented in classroom.
  • In vivo Imaging of Cancer therapy, Edited by Anthony F. Shields and Pat Price, Publisher: Humana, ISBN: 978-1617376849


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Last update: 18/03/2020 16:36
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