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Supramolecular and Bioinorganic Chemistry
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Supramolecular and Bioinorganic Chemistry
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Academic year 2020/2021
- Course ID
- BIO0168A Pds 306-TB
- Teacher
- Prof.ssa Simonetta Geninatti Crich
- Modular course
- CHEMISTRY FOR HEALTH SCIENCES (BIO0168 Pds 306-TB)
- Degree course
- [0101M21] Molecular Biotechnology
- Year
- 2nd year
- Teaching period
- To be defined
- Type
- Related or integrative
- Credits/Recognition
- 3
- Course disciplinary sector (SSD)
- CHIM/03 - chimica generale e inorganica
- Delivery
- Formal authority
- Language
- English
- Attendance
- Obligatory
- Type of examination
- Written and oral
- Prerequisites
- Inorganic chemistry Physical chemistry, Organic Chemistry, Biochemistry
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Sommario del corso
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Course objectives
The course aims at providing the students with the fundamentals of molecular recognition, of the interactions responsible for the formation of supramolecular systems and on the role of metals in biological systems and medicine. The student will be introduced to the principal classes of supramolecular systems (organic / inorganic of biological interest) together with the main techniques currently used for their characterization.
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Results of learning outcomes
- Knowledge of the nature of non-covalent interactions at the basis of the formation of supramolecular compounds which are held together by intermolecular bonds.
- Knowledge of the basic coordination chemistry and of the interdisciplinary approach to study the peculiar role of metals in biology and their interaction with organic and biological molecules.
-Basic knowledge of different spectroscopic techniques used to study metals in biological systems and intermolecular interactions.
- Capability to analyse data resulting from the methods indicated above
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Course delivery
20 hours lesson + 4 hours seminars
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Learning assessment methods
The examination is carried out in written/oral form¸ The final mark is expressed in thirtieths.
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Program
1) Principles of the molecular recognition (Hydrogen-bond and the weak intermolecular interactions, the coordinative bond; chelating effect)
2) The determination of the thermodynamic stability constant of host/guest supramolecular adducts
3) Organic and Inorganic supramolecular systems; Self-assembling systems: Cyclodesxtrins, Micelles and Liposomes; and their biomedical applications; molecular machines.
4) Basic coordination chemistry for biotechnologists.
5) Overview on spectroscopic methods to study metals in biological systems.
6) Biological ligands for metal ions.
7) Transition metals in biology; the role of Zn, Cu, Fe, Mn, Ni, Co
9) Metals in medicine
Suggested readings and bibliography
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1) Jonathan W. Steed, David R. Turner, Karl J. Wallace, ¸Core Concepts in Supramolecular Chemistry and Nanochemistry; Wiley, 2007.
2) JW Steed, JL Atwood Supramolecular Chemistry, Wiley, 2009.
3) RR Crichton Biological Inorganic Chemistry, Elsevier, 2013.
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Class schedule
Days Time Classroom Friday 11:00 - 13:00 Lessons: dal 12/10/2018 to 18/01/2019
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Note
The course will be delivered online with live lessons provided at the Moodle elearning platform at the following link
https://biotec.i-learn.unito.it/
Due to the COVID-19 sanitary emergency, the modality of course delivery could vary during the year. In any case, the "online" teaching will be guaranteed for the entire academic year.
Il corso sarà erogato in modalità telematica con lezioni in sincrono fruibili connettendosi alla piattaforma Moodle elearning al seguente link
https://biotec.i-learn.unito.it/
Le modalità di svolgimento dell'attività didattica potranno subire variazioni in base alle limitazioni imposte dalla crisi sanitaria in corso. In ogni caso è assicurata la modalità a distanza per tutto l'anno accademico
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