Master Program in Molecular Biotechnology

Supramolecular and Bioinorganic Chemistry

Supramolecular and Bioinorganic Chemistry

Academic year 2023/2024

Sommario del corso

• Course objectives
• Results of learning outcomes
• Program
• Course delivery
• Learning assessment methods
• Suggested readings and bibliography
• Notes
• Class schedule
• Teaching tools
• Course card

Course objectives

The course aims at providing the students with the fundamentals of molecular recognition, of the interactions responsible for the formation of supramolecular systems and on the role of metals in biological systems and medicine. The students will be introduced to the principal classes of supramolecular systems (organic / inorganic) of biological interest together with the main techniques currently used for their characterization.

Results of learning outcomes

- Knowledge of the nature of non-covalent interactions at the basis of the formation of supramolecular compounds which are held together by intermolecular bonds.

- Knowledge of the basic coordination chemistry and of the interdisciplinary approach to study the peculiar role of metals in biology and their interaction with organic and biological molecules.

- Knowledge of the characteristics of the main classes of supramolecular systems (Host-guest, self-assembled, coordination complexes)

-Basic knowledge of different spectroscopic techniques used to study metals in biological systems and intermolecular interactions.

- Capability to analyse data resulting from the methods indicated above

Program

1) Principles of the molecular recognition (Hydrogen-bond and the weak intermolecular interactions, the coordinative bond; chelating effect)

2) Organic and Inorganic supramolecular systems: Host-guest systems; Self-assembling systems (Micelles and Lipid belayers); and their biomedical applications;

3) Basic coordination chemistry for biotechnologists.

4) Biological ligands for metal ions.

5) Overview on spectroscopic methods to study supramolecular systems with a focus on NMR

 6) The determination of the thermodynamic stability constant of host/guest supramolecular adducts

Course delivery

The course will be delivered under the form of frontal lessons (20 hours). The last 4 hours of the course will be dedicated to flipped classroom activity where the students will be asked to present a selected paper describing a given supramolecular system.

Learning assessment methods

The assessment of learning outcomes will be carried out through a written examination (90 min) with five open questions on the main subjects of the course.

The final evaluation mark will be calculated based on the evaluation of the oral exposure of the selected paper (30% weight) and on the written examination (70% weight). 

1) Jonathan W. Steed, David R. Turner, Karl J. Wallace, ¸Core Concepts in Supramolecular Chemistry and Nanochemistry; Wiley, 2007.

2) JW Steed, JL Atwood Supramolecular Chemistry, Wiley, 2009.

3) RR Crichton Biological Inorganic Chemistry, Elsevier, 2013.

Notes

The course will be delivered online with live lessons provided at the Moodle elearning platform at the following link

https://biotec.i-learn.unito.it/ 

Due to the COVID-19 sanitary emergency, the modality of course delivery could vary during the year. In any case, the "online" teaching will be guaranteed for the entire academic year.

Il corso sarà erogato in modalità telematica con lezioni in sincrono fruibili connettendosi alla piattaforma Moodle elearning al seguente link

https://biotec.i-learn.unito.it/ 

Le modalità di svolgimento dell'attività didattica potranno subire variazioni in base alle limitazioni imposte dalla crisi sanitaria in corso. In ogni caso è assicurata la modalità a distanza per tutto l'anno accademico

Class schedule

• Teaching material
• Exams and finals
• Class schedule
• Go to Moodle
• Register for the course
• Enrolled students
• Invia email agli studenti registrati
• Export table