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Immuno-based assays for translational medicine II
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Immuno-based assays for translational medicine II
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Academic year 2023/2024
- Course ID
- BIO0163B Pds 308-BIDD
- Teacher
- Enzo Terreno (Lecturer)
- Degree course
- [0101M22] Molecular Biotechnology
- Year
- 2nd year
- Teaching period
- First semester
- Type
- Distinctive
- Credits/Recognition
- 2
- Course disciplinary sector (SSD)
- CHIM/03 - general and inorganic chemistry
- Delivery
- Formal authority
- Language
- English
- Attendance
- Obligatory
- Type of examination
- Written
- Type of learning unit
- modulo
- Modular course
- IMMUNO-BASED ASSAYS FOR TRANSLATIONAL MEDICINE (BIO0163 Pds 308-BIDD)
- Prerequisites
- Knowledge of the basics of the in vivo imaging technologies: PET, SPECT, MRI, Optical imaging, Ultrasound imaging, Photoacoustic imaging.
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Sommario del corso
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Course objectives
The main objectives of the module is:
- to provide the methodologies to conjugate imaging probes to immune-based systems
- to provide a comprehensive understanding of imaging probes based on antibodies, antibody fragments or derivatives, and antibody mimetics toi be used in in vivo imaging technologies
- to familiarize students with the different types of immune-based imaging agents and their applications in disease detection and monitoring.
- to examine the advancements and challenges in the development and translation of immune-based imaging agents from preclinical to clinical settings.
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Results of learning outcomes
Students will acquire an integrated comprehension of the design and use of immune-based imaging probes for in vivo molecular imaging procedures for diagnostic and theranostic purposes.
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Program
Introduction: use of immuno-based agents in diagnosis and theranosis
Bioconjugation: low-specific methods (amino groups)Bioconjugation: site-specific methods (cysteine – glycans – peptide tags – unnatural and noncanonical aminoacids)Use of antibodies in molecular imaging (target: HER2 – EGFR – FR - PSMA – CD20 – PD1/PDL1)Use of Antibody-Drug Conjugates in molecular imagingAntibody-based structures in molecular imaging (Ab fragments – Minibody – Diabody - Nanobody)Antibody mimetics in molecular imaging (DARPins – Monobodies – Anticalins – Affibodies – Affimers)Examples of immuno-based imaging by Optical/MRI/US technologies- Oggetto:
Course delivery
The lessons will be accompanied by material uploaded online on the Moodle platform. The students are invited to interact with the instructor by posing and answering questions
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Learning assessment methods
Learning will be assessed by a written examination in which students will be asked questions about the main topics of the course. The use of correct terminology and clarity of the exposition will be also evaluated.
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Support activities
Suggested readings and bibliography
- Enroll
- Closed
- Enrollment opening date
- 01/03/2020 at 00:00
- Enrollment closing date
- 31/12/2022 at 23:55
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