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IN VITRO DIAGNOSTICS: MOLECULAR PROFILING OF PROLIFERATIVE PROCESSES

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In vitro diagnostics: molecular profiling of proliferative processes

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Academic year 2021/2022

Course ID
BIO0171 Pds 306-TB
Teachers
Prof. Roberto Piva
Dott.ssa Claudia Voena
Degree course
[0101M22] Molecular Biotechnology
Year
1st year
Teaching period
Second semester
Type
Distinctive
Credits/Recognition
5
Course disciplinary sector (SSD)
MED/08 - anatomia patologica
Delivery
Formal authority
Language
English
Attendance
Obligatory
Type of examination
Oral
Type of learning unit
corso
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Sommario del corso

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Course objectives

The course aims to show how emerging technologies have contributed and still contribute to the comprehension of cancer and have changed the diagnostic procedures and therapeutic options for cancer patients, mainly focusing on hematological tumors. Through frontal lessons and the discussion of recent literature and milestones in this field of research, the course will provide the students with an overview of the impact of technology advancement on cancer research and with critical perspectives upon current and emerging cancer therapies, how they are developed, and how they are applied in the clinical setting. In addition, the most recent methodologies applied to cancer research will be discussed in detail.

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Results of learning outcomes

Students will gain knowledge of the progress in the diagnostic and treatment of cancer due to the advancement of biotechnology in this research field. 

Students will consolidate and develop a broad understanding of fundamental bases and emergent areas in the field of cancer, from the principles and applications of key techniques in molecular oncology to the identification of cancer vulnerabilities for targeted treatment.

The presentation sessions will allow students to develop critical reading, improve presentation skills, and critically assess experimental approaches and methodologies applied to cancer research.

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Program

The peer-review process

Hereditary cancers 

DNA Sequencing: Whole Exome Sequencing, Whole Genome Sequencing, Target sequencing

Expression profiling: from microarrays to (single-cell) RNA sequencing

The Cancer Genome Atlas (TCGA) – The Pan-Cancer Analysis Project - The Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium

Clonal Hematopoiesis and The Pre-Cancer Genome Atlas

Epigenetics and cancer

Hematological tumors: how molecular biology has revolutionized hematological tumor classification and therapy

Functional genomics: RNA interference, CRISPR/CAS9, drug screening

Tumor heterogeneity and clonal evolution 

Cancer vulnerabilities, drug resistance, persistence, and quiescence

Proteomics, proteogenomics for cancer diagnosis and treatment 

 

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Course delivery

The course is held 3 hours a week, for a total of 40 hours.

 Each lesson is divided into 2 sessions:

 - a frontal lesson with a slide presentation given by the teacher;

 - students' presentations of scientific papers including either a critical review or a methodological description of key and emerging technologies. All students are strongly encouraged to actively participate in the discussion. 

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Learning assessment methods

The presentation in class and other additional assignments such as paper peer-reviewing and gene variant classification will be evaluated as 1/3 of the total vote.

The final oral examination will evaluate the knowledge of the subjects of the course, the critical thinking skills, and the quality of the exposition. The vote will be expressed as a fraction of 30 (eventually cum laude).

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Support activities

Teachers are available for students by email or upon appointment to discuss issues related to the course.

Suggested readings and bibliography

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Slides and selected papers will be provided during the course.



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Notes

Le modalità di svolgimento dell'attività didattica potranno subire variazioni in base alle limitazioni imposte dalla crisi sanitaria in corso. In ogni caso è assicurata la modalità a distanza per tutto l'anno accademico

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