Molecular Therapy in Nephrology
Terapie molecolari in Nefrologia
Academic year 2019/2020
- Course ID
- Prof.ssa Benedetta Bussolati
- Degree course
- [0101M21] Molecular Biotechnology
- 2nd year
- Course disciplinary sector (SSD)
- MED/14 - nefrologia
- Formal authority
- Type of examination
- Type of learning unit
- Modular course
- THERAPEUTIC BIOTECHNOLOGY (BIO0169 Pds 306-TB)
- Basic knowledge on physiology, histology, cell and molecular biology and immunology.
Sommario del corso
Knowledge of the molecular and cellular mechanisms involved in the pathogenesis of the main kidney diseases and of bio-technological techniques for their therapy.
Results of learning outcomes
Knowledge of the molecular and cellular mechanisms involved in the pathogenesis of the main kidney diseases and of bio-technological techniques for their therapy, with specific focus on regenerative medicine.
- Pathogenetic mechanisms and development of molecular therapies:
Alterations of the immune system responsible for glomerular and tubulo-interstitial damage, autoimmunity, mechanism of the immune complex deposition. Strategies for the induction of tolerance. Mechanisms of glomerular permeability.
molecular and cellular mechanisms involved in the main clinical complications, theory and methodology for the development of techniques aimed to induce a specific immuno-suppression, tolerance or to modify the organ immunogenicity.
antigens and molecular mechanisms involved in the rejection of a xenogenic transplant, theory and methodology for the development of techniques aimed to improve the biocompatibility.
Resident and bone-marrow derived stem cells in the regeneration of the glomerular and tubular damage; stem cells and gene therapy, bioreactors.
Frontal lessons and presentation/discussion of literature papers.
Learning assessment methods
Suggested readings and bibliography
Didactic material (slides, text and articles) provided.
- Enrollment opening date
- 01/03/2020 at 00:00
- Enrollment closing date
- 31/12/2022 at 23:55