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Nanomaterials

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Nanomaterials

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Academic year 2021/2022

Course ID
BIO0160B Pds 307-DDD
Teachers
Prof. Gabriele Ricchiardi (Lecturer)
Prof.ssa Giuliana Magnacca
Degree course
[0101M21] Molecular Biotechnology
Year
2nd year
Teaching period
To be defined
Type
Distinctive
Credits/Recognition
5
Course disciplinary sector (SSD)
CHIM/02 - chimica fisica
Delivery
Formal authority
Language
English
Attendance
Obligatory
Type of examination
Written
Type of learning unit
modulo
Modular course
ADVANCED MATERIALS AND METHODS FOR HEALTH SCIENCES (BIO0160 Pds 307-DDD)
CHEMISTRY FOR HEALTH SCIENCES (BIO0168 Pds 306-TB)
Prerequisites
- basic knowledge in Physical-Chemistry (structure of matter; intermolecular interactions; thermodynamic of molecular systems; main molecular spectroscopic methods)
- basic knowledge in Physiscs (nature of electromagnetic radiation, electric dipoles; Coulomb interactions; elastic and inelastic interactions)
- basic knowledge in biochemistry
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Sommario del corso

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Course objectives

The objectives proosed to the studentd as targets of this course are aimed to the achievements of good capabilities dealing with:
- establishment of relationships between the features of amphiphlic molecules/self-assembled amphiphilic molecules and their functional behaviours relevant for their use in nanobiotechnology
- establishment of relationships between features of inorganic nanoparticles and their functional behaviours relevant for their use in nanobiotechnology
- selection and aplication of proper experimental methods for the study of nanobiotecnological systems

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Results of learning outcomes

 

A: KNOWLEDGE AND UNDERSTANDING

  • main methods for the preparation and characterization of main classes of nanomaterials of interest in biotechnology
  • fundamental aspects of physical and physical-chemical features of nanomaterials at the basis of their possible exploitation in biotechnology
  • fundamental aspects of the combined use of nanoparticles and biomacromolecules
  • electron microscopy of biological/biotechnological interest.

B: APPLYING KNOWLEDGE AND UNDERSTANDING

  • establishing correct causal relationships when discussing the fnctional behaviour of nanomaterials
  • selection of the effective characterization techniques of nanomaterials of interest for biotechnology
  • capability to select the proper electron microscopy methods and signals for the investigation of samples

C: MAKING JUDGEMENTS

  • capability to critically analysing the scientific literature

D: COMMUNICATION

  • abilty to use the technical vocabulary of research in the field
E: LIFELONG LEARNING SKILLS
  • ability to understand future literature in the field of nanomaterials and electron microscopy, in particular when applied to biotechnology
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Program

This course is devoted to the knowledge and understanding of physical-chemical features of naomaterials at the basis of their functional behaviours which can be exploited for biotechnological applications.
The topics will then deal with:
"soft" nanomaterials
- self-assembling of amphiphilic molecules resulting in the formation of micelles
- relationships between compositional and structural features of amphiphilic molecules and structure and functional behaviour of micelles
- methods for the characterization of micelles-based nanomaterials
- cases-study related to actual or potential application of self-assembled soft materials in biotechnology (e.g, drug delivery, gene therapy)

"hard" nanomaterials
- oxide nanoparticles (typically made of silica), hybridized with fluorophores, intented for applications in "in vitro" and "in vivo" optical imaging: preparation, characterization, surface functionalization for targeting, possible uses
- metal nanoparticles(typically made of gold): origin and dependences of peculiar optical behaviours (plasmon resonance, effect on the emission features of nearby fluorophores), possible uses in cellular and molecular biology
Imaging of nanoparticles: electron microscopy
Scanning electron microscopy: principles; signals to be exploited for the formation of images; type of information present in the images depending on teh signal collected; sample preparation; uses in biology/biotechnology
Transmission electron microscopy: principles; origin and importance of the high resolution, sample preparation; uses in biology/biotechnology
Chemical analysis by energy dispersion spectroscopy of X-rays emitted by samples impinged by a beam of accelerated electrons: principles; uses in biology/biotechnology

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Course delivery

The topic "soft and hard nanomaterials" (3CFU) will be taught by Prof. Ricchiardi, while the topic "electron microscopy" (2CFU) will be taught by Prof. Martra.

Traditional lessons in presence if possible. In case the lessons will not be feasible, the lessons will be delivered in one of the following forms, according to the technical means provided by the University:

- audio/video recording of the lessons (streaming and/or off-line)

- audio recording over Powerpoint presentations (off-line)

If an off-line form will be adopted, regular meetings online with students for Q&A will be offered.

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Learning assessment methods

For the autumn sessions 2020, the examination will be in oral form via Webex (one of the possible choiches present in the Rectoral Decree  2576/2020 on 23.07.2020).
 
This info will be updated when the University will communicate new rules.
 
In general, in a future, when exams in presence will be the only form allowed: written examination with 5 open questions.
 

Suggested readings and bibliography

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- I.A. Israelechvili, Intermolecular and surface forces, Wiley&Sons, Chichester-UK, 1999, second edition

- J.I. Goldstein et al., Scanning Electron Microscopy and X-Ray Microanalysis : A Text for Biologists, Materials Scientists, and Geologists, Springer-Verlag New York Inc., New York 2011, 

- William & Carter, Transmission electron Microscopy, Interscientia, San Diego, 2002, second edition

- scientific papers, uploaded on the webpage of the course



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Notes

Le modalità di svolgimento dell'attività didattica potranno subire variazioni in base alle limitazioni imposte dalla crisi sanitaria in corso. In ogni caso è assicurata la modalità a distanza per tutto l'anno accademico

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