SUPRAMOLECULAR CHEMISTRY AND SPECTROSCOPIC METHODS
Supramolecular chemistry and Spectroscopic methods
Academic year 2022/2023
- Course ID
- BIO0153 Pds 308-BIDD
- Gloria Berlier
Simonetta Geninatti Crich
- Degree course
- [0101M22] Molecular Biotechnology
- 1st year
- Teaching period
- To be defined
- Course disciplinary sector (SSD)
- CHIM/03 - general and inorganic chemistry
- Formal authority
- Type of examination
- Written and oral
- -General chemistry,
-Basis of organic chemistry and biochemistry (functional groups, reactivity, structure of biological macromolecules, ...)
-Knowledge about physic of electromagnetic waves,
-Basis of cell and molecular biology.
Sommario del corso
The course aims at providing the students with the fundamentals of supramolecular chemistry and spectroscopies for application in biomedicine.
Supramolecular chemistry has primarily found its inspiration in biological molecules, such as proteins, lipids, sugars and nucleic acids and their interactions. Currently the supramolecular assembly of designed compounds can be controlled to great extent. This provides the opportunity to combine these synthetic supramolecular elements with biomolecules for the study of biological phenomena and the development of new drugs and diagnostic agents.
In particular, the first part of the course deals with the understanding of molecular recognition, of the interactions responsible for the formation of supramolecular systems, the role of metals in biological systems and medicin.
The second part of the course deals with the basis and application of spectroscopic tecniques in biological research (UV-Vis, fluorescence, IR, NMR). It will provide tools for studing biological systems and intermolecular interactions.
Results of learning outcomes
-Knowledge of the nature of non-covalent interactions at the basis of the formation of supramolecular systems.
- Knowledge of the basic coordination chemistry and of the interdisciplinary approach to study the peculiar role of metals in biology and their interaction with organic and biological molecules.
-Basic knowledge of the roles of metals in biological systems and coordination chemistry.
-Knowledge of Nuclear Magnetic resonance (NMR) principles and main applications in biomedicine.
-Knowledge of optical spectroscopies (UV-Vis, fluorescence, IR) and main applications in biomedicine.
The course is divided in two modules:
-supramolecular and bioinorganic chemistry (prof. G. Ferrauto). The module is focused on supramolecular chemistry description (basic concepts and biomedical applications). A particular focus will be devoted to the understanding of the fundamentals of molecular recognition (host-guest), the chemical interactions responsible for the formation of biological membranes and supramolecular systems, the role of metals in biological systems and medicine and basis of coordination chemistry.
-spectroscopy of biomolecules (prof. G Berlier, prof. S. Geninatti Crich). This module has the aim of providing the physical theoretical and practical concepts of the main spectroscopic methods currently used in biological research (UV-Vis, fluorescence, IR, NMR) fundamental for the study of the intermolecular interactions.
A detailed description of the two modules are in the corresponding module webpage.
The course will be delivered through lessons in the lecture room (90%) and in labs (10%), for focus on some methodological aspects.
The course is divided into three part:
-Supramolecular chemistry (3 CFU, 24h)- Module 1
-Nuclear Magnetic Resonance NMR (3 CFU, 24 h)- Module 2
-Electronic (absorption and emission) spectroscopies (2 CFU, 16 h)- Module 2
Learning assessment methods
The exam will be written + oral. The final score will be the weighted mean of the three parts of the course.
The "laude" will be granted to students who have obtained 30/30 in each part of the exam and at least one "laude".
The teachers are avaiable for questions and doubts by mail, face to face (if possible) or webex meetings.
Suggested readings and bibliography
For the current a.a the lessons will be held in presence.
For the current a.a. the lessons will also be streamed online via the personal Webex pages of the teachers, exclusively for students seriously unable to attend the lessons in the presence.
The first lesson of prof. Berlier will be on 04 October from 14:00 to 16:00 followed by the lesson of prof. Geninatti from 16:00 to 18:00 in Aula Leonardo (MBC) via Nizza 52 and respectively at the following links:
The first lesson of Prof. Ferrauto will be on 10 october 9.00-11:00 in Aula Mendel (MBC) via Nizza 52 and at the following link:
Due to the COVID-19 sanitary emergency, the modality of course delivery could vary during the year.
- Spectroscopy of biomolecules (BIO0153B Pds 308-BIDD)
- Supramolecular and bioinorganic chemistry (BIO0153A Pds 308-BIDD)